I received my Dunlop D606s for my WR250R last Friday, but I didn't receive the new heavy duty tubes to go with them. Since I was lazy and didn't want to remove the tires twice, I waited. Last night I was finally able to get them installed! This is my first time changing motorcycle tires, so I hope I don't pinch a tube.
We will be installing:
Dunlop D606 90/90-21 Front Tire
Dunlop D606 120/90-18 Rear Tire
Fly Racing Heavy Duty Tube - 4.50/5.10-18 Rear
The first step for me was to remove the front tire. I used a 22mm wrench for the axle and a 10mm wrench for the axle pinch bolts. Then slide the spacers and the axle out. 
Breaking the bead before using the tire spoons! 
Then carefully remove the tire and tube. I want to use the stock tubes to carry as spares since they pack quite small compared to the new HD tubes. 
Here the stock Trailwing TW301/TW302, D606, and a dirt bike tire are compared: 
As you can see, the D606 seems to be a good street-able balance between the three, it is also about an inch more in diameter compared to the trailwing.
Here is the new Fly HD rear tube compared to the stock rear tube. The Fly HD is on the top. 
These are the two best tools you can have when changing a tire: 
(an extra pair of hands, not the gloves!)
The finished front and rear: 
Luckily, I didn't pinch either of the new tubes or the old tubes. The new tires are much more substantial than the stock trailwings. The tire carcass is much stiffer and the knobs much taller.
I haven't had the chance to test the tires in the sand yet, but they seem great so far on gravel and the street. I can't wait to finish breaking them in to really test them on the street.
Specs on the tires:
Dunlop D606 Dual Sport - 90/90-21 Front
Dunlop D606 Dual Sport - 120/90-18 Rear
Specs on the tubes:
Fly Racing Heavy Duty Tube - 2.75/3.00-21 Front
Fly Racing Heavy Duty Tube - 4.50/5.10-18 Rear
UPDATE: 2000 miles later, I’m loving this setup. The D606s work better on every surface compared to stock.
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